Speaking in front of a packed 70,000 crowd at the Millennium stadium in Cardiff at the weekend, the band paid homage to The Edge's Welsh roots with Bono confessing to having once had singing lessons from the guitarist's father, Garvin Evans.
"He told me to look after the consonants and the vowels will look after themselves," Bono told the crowd.
The Edge, whose family were in the Cardiff crowd on Saturday showed that his true Welsh roots by saying "Cymru Am Byth", before the band launched into "I Still Haven't Found What I'm Looking For" with the crowd going wild.
And for the new CEO of the Scarlets, Paul Sergeant who arrived in Llanelli from Australia last week, Saturday night's concert brought back great memories of the U2 concert he brought to Wales at the Millennium stadium in June 2005.
"It was great to see the band back in Wales and getting such a rapturous reception. U2 are arguably one of the world's biggest stadium rock bands and it's brilliant to see that they are so proud of The Edge's Welsh connection."
Sergeant first worked with U2 during their Zooropa Tour in 1993 when he was responsible for their merchandising operation. He worked with them on the Tsunami Relief Concert in January 2005 when he was General Manager of the Millennium stadium. He received an OBE for this work on the famous fund-raising concert - organised in just a fortnight. He then brought U2 back to Wales as part of their world tour just five months later.
He said that Llanelli was obviously important to the renowned guitarist and his family.
"He's still very true to his parent's Welsh roots and it's obvious that Llanelli is an important place for his family - to see global superstars paying tribute the town at the weekend was wonderful to see."
Edge's Mum Gwenda said of her famous son, real name Dave Evans, has always had a warm welcome in Wales since his rise to stardom. The family moved to Ireland shortly after Dave was born but music was part of family life from the start.
"I call him Dave, but most of the time when I'm talking about him, I call him Edge because people know him as that. Music was always part of our lives. I used to sing to the children, so he had a good ear for music at a very young age. All three of them have. People say to me I must be very proud of Edge and I tell them I'm proud of all of my children.
"Wales is about singing - my family sang in choirs and the same with Garvin. The churches we went to, the whole congregation sang in harmony and a lot of hymns would be part of our service. I suppose it's grown into you in Wales."
The Edge's Llanelli roots also connect to another famous musician, and a cousin of his, who is currently lecturing at Coleg Sir Gâr and was Catatonia's drummer, his name is Aled Richards.